Personality and genes: remarks from a biological perspective
More details
Hide details
Submission date: 2014-08-22
Acceptance date: 2014-10-03
Online publication date: 2014-10-23
Publication date: 2014-10-23
Current Issues in Personality Psychology 2014;2(3):133-140
Although there is no doubt that genes’ functions influence human personality, years of studies provided no clear picture on regulation of particular traits by specific genes. In this article, an overview of the complexity of the system of genetic control of personality is presented, and the level of complications of biological processes operating in this system is underlined. The methodology of studies devoted to determine effects of genes on personality traits is discussed, and limitations of various methods in such studies are indicated. Finally, suggestions for further research are listed and commented on. It is likely that to increase the level of our understanding of genetic mechanisms that modulate human personality, researchers conducting further studies will have to focus on using large sample sizes, performing independent replications, considering experiments on animal models, integrating cross-cultural data and epigenetic measures, and performing interdisciplinary experiments which combine methods of various disciplines, such as biology and psychology.
Amad, A., Ramoz, N., Thomas, P., Jardri, R., & Gorwood, P. (2014). Genetics of borderline personality disorder: systematic review and proposal of an integrative model. Neuroscience & Biobehavioral Reviews, 40, 6-19.
Balestri, M., Calati, R., Serretti, A., & De Ronchi, D. (2014). Genetic modulation of personality traits: a systematic review of the literature. International Clinical Psychopharmacology, 29, 1-15.
Bellettato, C. M., & Scarpa, M. (2010). Pathophysiology of neuropathic lysosomal storage disorders. Journal of Inherited Metabolic Disease, 33, 347-362.
Bloch, S., Nejman-Faleńczyk, B., Łoś, J. M., Barańska, S., Łepek, K., Felczykowska, A., Łoś, M., Węgrzyn G., & Węgrzyn, A. (2013). Genes from the exo-xis region of λ and Shiga toxin-converting bacteriophages influence lysogenization and prophage induction. Archives of Microbiology, 195, 693-703.
Buades-Rotger, M., & Gallardo-Pujol, D. (2014). The role of the monoamine oxidase A gene in moderating the response to adversity and associated antisocial behavior: a review. Psychology Research and Behavior Management, 7, 185-200.
Calati, R., Signorelli, M. S., Gressier, F., Bianchini, O., Porcelli, S., Comings, D. E., De Girolamo, G., Aguglia, E., MacMurray, J., & Serretti, A. (2014). Modulation of a number of genes on personality traits in a sample of healthy subjects. Neuroscience Letters, 566, 320-325.
Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., & Poulton, R. (2002). Role of genotype in the cycle of violence in maltreated children. Science, 297, 851-854.
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., & Poulton, R. (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science, 301, 386-389.
Cicchetti, D., Rogosch, F. A., Hecht, K. F., Crick, N. R., & Hetzel, S. (2014). Moderation of maltreatment effects on childhood borderline personality symptoms by gender and oxytocin receptor and FK506 binding protein 5 genes. Development and Psychopathology, 26, 831-849.
Florio, M., & Huttner, W. B. (2014). Neural progenitors, neurogenesis and the evolution of the neocortex. Development, 141, 2182-2194.
Glaser, Y. G., Zubieta, J. K., Hsu D. T., Villafuerte, S., Mickey, B. J., Trucco, E. M., Burmeister, M., Zucker, R. A., & Heitzeg, M. M. (2014). Indirect effect of corticotropin-releasing hormone receptor 1 gene variation on negative emotionality and alcohol use via right ventrolateral prefrontal cortex. The Journal of Neuroscience, 34, 4099-4107.
Hammen, C., Bower, J. E., & Cole, S. W. (in press). Oxytocin receptor gene variation and differential susceptibility to family environment in predicting youth borderline symptoms. Journal of Personality Disorders. DOI: 10.1521/pedi_2014_28_152.
Jakóbkiewicz-Banecka, J., Gabig-Cimińska, M., Banecka-Majkutewicz, Z., Banecki, B., Węgrzyn, A., & Węgrzyn, G. (2014). Factors and processes modulating phenotypes in neuronopathic lysosomal storage diseases. Metabolic Brain Disease, 29, 1-8.
Kwan, J. J., Smirnova, E., Khazai, S., Evanics, F., Maxwell, K. L., & Donaldson, L. W. (2013). The solution structures of two prophage homologues of the bacteriophage λ Ea8.5 protein reveal a newly discovered hybrid homeodomain/zinc-finger fold. Biochemistry, 52, 3612-3614.
Laplana, M., Royo, J. L., García, L. F., Aluja, A., Gomez-Skarmeta, J. L., & Fibla, J. (in press). SIRPB1 copy-number polymorphism as candidate quantitative trait locus for impulsive-disinhibited personality. Genes, Brain and Behavior. DOI: 10.1111/gbb.12154.
Martín-Blanco, A., Ferrer, M., Soler, J., Salazar, J., Vega, D., Andión, O., Sanchez-Mora, C., Arranz, M. J., Ribases, M., Feliu-Soler, A., Pérez, V., & Pascual, J. C. (2014). Association between methylation of the glucocorticoid receptor gene, childhood maltreatment, and clinical severity in borderline personality disorder. Journal of Psychiatric Research, 57, 34-40.
Montag, C., & Reuter, M. (2014). Disentangling the molecular genetic basis of personality: from monoamines to neuropeptides. Neuroscience & Biobehavioral Reviews, 43, 228-239.
Montag, C., Kunz, L., Axmacher, N., Sariyska, R., Lachmann, B., & Reuter, M. (2014). Common genetic variation of the APOE gene and personality. BMC Neuroscience, 15, 64.
Munafò, M. R., & Flint, J. (2011). Dissecting the genetic architecture of human personality. Trends in Cognitive Sciences, 15, 395-400.
Napolioni, V., Murray, D. R., Comings, D. E., Peters, W. R., Gade-Andavolu, R., & MacMurray, J. (2014). Interaction between infectious diseases and personality traits: ACP1*C as a potential mediator. Infection, Genetics and Evolution, 26, 267-273.
Olszewski, P., Szambowska, A., Barańska, S., Narajczyk, M., Węgrzyn, G., & Glinkowska, M. (2014). A dual promoter system regulating λ DNA replication initiation. Nucleic Acids Research, 42, 4450-4462.
Schwartz, N., Temkin, P., Jurado, S., Lim, B. K., Heifets, B. D., Polepalli, J. S., & Malenka, R. C. (2014). Chronic pain. Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens. Science, 345, 535-542.
Tekkalaki, B., Tripathi, A., & Trivedi, J. K. (2014). Welcome biological breakthroughs, supply psychosocial insights. Mens Sana Monographs, 12, 79-91.
Węgrzyn, G., Jakóbkiewicz-Banecka, J., Narajczyk, M., Wiśniewski, A., Piotrowska, E., Gabig-Cimińska, M., Kloska, A., Słominska-Wojewodzka, M., Korzon-Burakowska, A., & Węgrzyn, A. (2010). Why are behaviors of children suffering from various neuronopathic types of mucopolysaccharidoses different? Medical Hypotheses, 75, 605-609.
Węgrzyn, G., Licznerska, K., & Węgrzyn, A. (2012). Phage λ – new insights into regulatory circuits. Advances in Virus Research, 82, 155-178.
Wraith, J. E. (2013). Mucopolysaccharidoses and mucolipidoses. Handbook of Clinical Neurology, 113, 1723-1729.
Yuan, L., & Hassan, B. A. (2014). Neurogenins in brain development and disease: an overview. Archives of Biochemistry and Biophysics, 58, 10-13.
Copyright: © Institute of Psychology, University of Gdansk This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Journals System - logo
Scroll to top